https://scholars.lib.ntu.edu.tw/handle/123456789/601376
Title: | Fabrication of Multiresponsive Magnetic Nanocomposite Double-Network Hydrogels for Controlled Release Applications | Authors: | Lu C.-H Yeh Y.-C. YI-CHEUN YEH |
Keywords: | Hydrogels;Hydrogen bonds;Iron oxides;Medical applications;Nanomagnetics;Nanoparticles;Controlled release;Double network;Double-network hydrogels;Dynamic covalent bond;High mechanical strength;Magnetic nanocomposites;Multi-responsive;Nanocomposite hydrogels;Property;Stimuli responsiveness;Nanocomposites;biomaterial;nanocomposite;delayed release formulation;hydrogel;magnetism;Biocompatible Materials;Delayed-Action Preparations;Magnetic Phenomena | Issue Date: | 2021 | Journal Volume: | 17 | Journal Issue: | 52 | Source: | Small | Abstract: | Nanocomposite double-network hydrogels (ncDN hydrogels) have been demonstrated as promising biomaterials to present several desired properties (e.g., high mechanical strength, stimuli-responsiveness, and local therapy) for biomedicine. Here, a new type of ncDN hydrogels featuring definable microstructures and properties as well as multistimuli responsiveness for controlled release applications is developed. Amine-functionalized iron oxide nanoparticles (IOPs_NH2) are used as nanoparticle cross-linkers to simultaneously connect the dual networks of gelatin (Gel) and polydextran aldehyde (PDA) through hydrogen bonding, electrostatic interactions, and dynamic imine bonds. The pH- and temperature-responsive Gel/PDA/IOP_NH2 ncDN hydrogels present a fast release profile of proteins at acidic pH and high temperature. Besides, IOP_NH2 also contributes the magnetic-responsiveness to the ncDN hydrogels, allowing the use of magnetic field to generate heat to facilitate the structural change of hydrogels and the subsequent applications. Taken together, a versatile ncDN hydrogel platform capable of multistimuli responsiveness and local heating for controlled release is developed for advanced biomedical applications. ? 2021 Wiley-VCH GmbH |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119158401&doi=10.1002%2fsmll.202105997&partnerID=40&md5=089bf7bcfad4d3bfedb489061711e24e https://scholars.lib.ntu.edu.tw/handle/123456789/601376 |
ISSN: | 16136810 | DOI: | 10.1002/smll.202105997 |
Appears in Collections: | 高分子科學與工程學研究所 |
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