https://scholars.lib.ntu.edu.tw/handle/123456789/605778
標題: | Pepsin-digested chicken-liver hydrolysate attenuates hepatosteatosis by relieving hepatic and peripheral insulin resistance in long-term high-fat dietary habit | 作者: | Wu, Yi-Hsieng Samuel Lin, Yi-Ling WEN-YUAN YANG SHENG-YAO WANG YI-CHEN CHEN |
關鍵字: | Adipose tissue;Chicken-liver hydrolysates;Insulin resistance;Non-alcoholic fatty liver disease;Skeletal muscle;alanine aminotransferase;albumin;alkaline phosphatase;aspartate aminotransferase;catalase;fatty acid;glucose;glutathione;glutathione peroxidase;insulin;interleukin 1beta;ketone body;liver protective agent;oleic acid;pepsin A;protein hydrolysate;superoxide dismutase;thiobarbituric acid reactive substance;triacylglycerol;tumor necrosis factor;alanine aminotransferase blood level;albumin blood level;alkaline phosphatase blood level;animal cell;animal experiment;animal model;animal tissue;Article;aspartate aminotransferase blood level;body weight gain;cell degeneration;chicken;cholesterol blood level;controlled study;eating habit;fatty acid blood level;fatty liver;FL83B cell line;glucose blood level;in vitro study;in vivo study;insulin resistance;lipid diet;lipid storage;liver protection;liver tissue;male;mouse;nonhuman;steatosis;stimulation;triacylglycerol blood level;trolox equivalent antioxidant capacity;upregulation | 公開日期: | 2021 | 卷: | 29 | 期: | 2 | 起(迄)頁: | 375-388 | 來源出版物: | Journal of Food and Drug Analysis | 摘要: | This study aims to clarify the effects of chicken liver hydrolysates (CLHs) on long-term high-fat diet (HFD)-induced insulin resistance (IR) and hepatosteatosis in mice. In vitro, the 400 mM oleic acid (OA)-added medium successfully stimulated the cellular steatosis on FL83B cells, and the cellular steatosis was attenuated ( p < 0.05) by supplementing with CLHs (4 mg/L). In vivo, the effects of CLHs on IR and hepatosteatosis development were tested in 20-week HFD-fed mice. HFD-induced increases in final body weight, but body weight gains of mice were decreased ( p < 0.05) by supplementing CLHs. Elevated ( p < 0.05) serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), free fatty acids (FFAs), triglyceride (TG), total cholesterol (TC), and fasted glucose values in HFD-fed mice decreased ( p < 0.05) by supplementing CLHs. Both results of hepatic steatosis and fibrotic scores also indicated the retardation ( p < 0.05) of the hepatosteatosis in cotreated groups. Moreover, the CLH supplementation sustained ( p < 0.05) hepatic and peripheral insulin signal sensitivity in HFD-fed mice. CLH supplementation could ameliorate hepatic lipid deposition, hepatic/peripheral IR in a long-term high-fat dietary habit, and also improve the universal glucose homeostasis by upregulating hepatic and peripheral insulin sensitivities. ? 2021, Taiwan Food and Drug Administration. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110287231&doi=10.38212%2f2224-6614.3351&partnerID=40&md5=db1b2a60d5f3cba469d131d9447f19db https://scholars.lib.ntu.edu.tw/handle/123456789/605778 |
ISSN: | 10219498 | DOI: | 10.38212/2224-6614.3351 |
顯示於: | 氣候變遷與永續發展國際學位學程(含碩士班、博士班) |
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