https://scholars.lib.ntu.edu.tw/handle/123456789/606144
標題: | Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice | 作者: | Hung W.-L Hsiao Y.-T Chiou Y.-S Nagabhushanam K Ho C.-T MIN-HSIUNG PAN |
關鍵字: | Mammals;Metabolites;Anti-inflammatory effects;Broad spectrum;Chemopreventive effects;Grape wine;Health benefits;Hepatoprotective effects;Liver fibrosis;Natural analog;Piceatannol;Red wine;Collagen;3,3',4,5'-tetrahydroxystilbene;antioxidant;carbon tetrachloride;resveratrol;stilbene derivative;animal;body weight;drug effect;liver cirrhosis;male;metabolism;mouse;Vitis;Animals;Antioxidants;Body Weight;Carbon Tetrachloride;Liver Cirrhosis;Male;Mice;Resveratrol;Stilbenes | 公開日期: | 2021 | 卷: | 12 | 期: | 22 | 起(迄)頁: | 11229-11240 | 來源出版物: | Food and Function | 摘要: | Piceatannol (3,5,3′,4′-trans-tetrahydroxystilbene) is a natural analog and a metabolite of resveratrol present in grapes and red wine. Previous studies have reported that piceatannol exerts a broad spectrum of health benefits including antioxidant, anti-inflammatory, chemopreventive, and neuroprotective effects. However, little is known about the hepatoprotective effect of piceatannol against toxin-induced liver fibrosis. Therefore, the objective of this study is to evaluate the protective effect of piceatannol in a mouse model of CCl4-induced hepatic fibrosis. Oral administration of piceatannol significantly improved the hepatic functions of CCl4-treated mice in both therapeutic and preventive models. Additionally, the immunohistochemical staining results revealed that collagen deposition in CCl4-injected mice was significantly reduced by treatment with piceatannol. Moreover, piceatannol remarkably suppressed the expressions of collagen I, α-smooth muscle protein (α-SMA), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) induced by CCl4. The anti-fibrotic mechanism of piceatannol was associated with the regulation of the transforming growth factor-β (TGF-β)/Smad signaling pathway. Finally, piceatannol also profoundly alleviated CCl4-induced hepatic oxidative damage by elevating the level of glutathione and catalase activity. Altogether, our current findings suggest that piceatannol may serve as a bioactive agent that inhibits or alleviates toxic-induced fibroproliferative diseases, especially in the prevention of liver fibrosis. ? The Royal Society of Chemistry. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119719483&doi=10.1039%2fd1fo02545g&partnerID=40&md5=b20e64ea227ec82df7be0d5d03211896 https://scholars.lib.ntu.edu.tw/handle/123456789/606144 |
ISSN: | 20426496 | DOI: | 10.1039/d1fo02545g |
顯示於: | 食品科技研究所 |
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