Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice
Journal
Food and Function
Journal Volume
12
Journal Issue
22
Pages
11229-11240
Date Issued
2021
Author(s)
Abstract
Piceatannol (3,5,3′,4′-trans-tetrahydroxystilbene) is a natural analog and a metabolite of resveratrol present in grapes and red wine. Previous studies have reported that piceatannol exerts a broad spectrum of health benefits including antioxidant, anti-inflammatory, chemopreventive, and neuroprotective effects. However, little is known about the hepatoprotective effect of piceatannol against toxin-induced liver fibrosis. Therefore, the objective of this study is to evaluate the protective effect of piceatannol in a mouse model of CCl4-induced hepatic fibrosis. Oral administration of piceatannol significantly improved the hepatic functions of CCl4-treated mice in both therapeutic and preventive models. Additionally, the immunohistochemical staining results revealed that collagen deposition in CCl4-injected mice was significantly reduced by treatment with piceatannol. Moreover, piceatannol remarkably suppressed the expressions of collagen I, α-smooth muscle protein (α-SMA), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) induced by CCl4. The anti-fibrotic mechanism of piceatannol was associated with the regulation of the transforming growth factor-β (TGF-β)/Smad signaling pathway. Finally, piceatannol also profoundly alleviated CCl4-induced hepatic oxidative damage by elevating the level of glutathione and catalase activity. Altogether, our current findings suggest that piceatannol may serve as a bioactive agent that inhibits or alleviates toxic-induced fibroproliferative diseases, especially in the prevention of liver fibrosis. ? The Royal Society of Chemistry.
Subjects
Mammals
Metabolites
Anti-inflammatory effects
Broad spectrum
Chemopreventive effects
Grape wine
Health benefits
Hepatoprotective effects
Liver fibrosis
Natural analog
Piceatannol
Red wine
Collagen
3,3',4,5'-tetrahydroxystilbene
antioxidant
carbon tetrachloride
resveratrol
stilbene derivative
animal
body weight
drug effect
liver cirrhosis
male
metabolism
mouse
Vitis
Animals
Antioxidants
Body Weight
Carbon Tetrachloride
Liver Cirrhosis
Male
Mice
Resveratrol
Stilbenes
SDGs
Type
journal article