https://scholars.lib.ntu.edu.tw/handle/123456789/606923
Title: | Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy | Authors: | Yu S Jang D Yuan H Huang W.-T Kim M Marques Mota F RU-SHI LIU Lee H Kim S Kim D.H. |
Keywords: | localized surface plasmon resonance;photosensitizer;phototherapy;titanium dioxide;upconversion;Cell death;Hot electrons;Infrared devices;Nanorods;Photodynamic therapy;Plasmonics;Titanium dioxide;Cancer cells;Hot carrier injection;Localized surface plasmon resonance;Near infrared light;Photo-thermal;Photosensitiser;Phototherapy;Up-conversion;Up-conversion emission;Upconversion nanoparticles;Photosensitizers | Issue Date: | 2021 | Journal Volume: | 13 | Journal Issue: | 49 | Start page/Pages: | 58422-58433 | Source: | ACS Applied Materials and Interfaces | Abstract: | Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO2@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO2) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO2 and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO2, generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO2 (77.3%) and UCNP@aTiO2 (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO2@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agents, providing a valuable addition to light-triggered cancer treatments in deep tissue. ? 2021 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120920013&doi=10.1021%2facsami.1c21949&partnerID=40&md5=ea4496cfb12b6a0aa36115c189d64473 https://scholars.lib.ntu.edu.tw/handle/123456789/606923 |
ISSN: | 19448244 | DOI: | 10.1021/acsami.1c21949 |
Appears in Collections: | 化學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.