https://scholars.lib.ntu.edu.tw/handle/123456789/607083
標題: | Pilot study of focused ultrasound for drug-resistant epilepsy | 作者: | Lee C.-C Chou C.-C Hsiao F.-J Chen Y.-H Lin C.-F Chen C.-J Peng S.-J Yu H.-Y. HAO-LI LIU |
公開日期: | 2022 | 卷: | 63 | 期: | 1 | 起(迄)頁: | 162-175 | 來源出版物: | Epilepsia | 摘要: | Objective: The neuromodulatory effects of focused ultrasound (FUS) have been demonstrated in animal epilepsy models; however, the safety and efficacy of FUS in humans with epilepsy have not been well established. Patients with drug-resistant epilepsy (DRE) undergoing stereo-electroencephalography (SEEG) provide an opportunity to investigate the neuromodulatory effects of FUS in humans. Methods: Patients with DRE undergoing SEEG for localization of the seizure onset zone (SOZ) were prospectively enrolled. FUS was delivered to the SOZ using a neuronavigation-guided FUS system (ceiling spatial-peak temporal-average intensity level?=?2.8?W/cm2, duty cycle?=?30%, modulating duration?=?10?min). Simultaneous SEEG recordings were obtained during sonication and for 3?days after treatment. Seizures, interictal epileptiform discharges, and adverse events after FUS were monitored. Results: Six patients met the eligibility criteria and completed FUS treatment. A decrease in seizure frequency was observed in two patients within the 3-day follow-up; however, one patient presented an increase in the frequency of subclinical seizures. Posttreatment magnetic resonance imaging revealed neither lesion nor brain edema. Significant changes in spectral power of SEEG were noted at the targeted electrodes during FUS treatment. One patient reported subjective scalp heating during FUS, and one patient developed transient naming and memory impairment that resolved within 3 weeks after FUS. Significance: FUS can be safely delivered to the SOZ of patients with DRE, resulting in significant changes in spectral power of SEEG. A larger sample cohort and pursuing optimal sonication parameters will be required to elucidate the neuromodulatory effects of FUS when used for seizure control. ? 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118396670&doi=10.1111%2fepi.17105&partnerID=40&md5=bb2af5fc133126a5394213f833d2fa12 https://scholars.lib.ntu.edu.tw/handle/123456789/607083 |
ISSN: | 00139580 | DOI: | 10.1111/epi.17105 | SDG/關鍵字: | adolescent; adult; Article; body temperature; child; clinical article; computed tomographic angiography; computer assisted tomography; drug resistant epilepsy; electroencephalogram; eligibility criteria; epileptic discharge; female; focused ultrasound therapy; follow up; Fourier transform; functional neuroimaging; general hospital; human; information processing; male; memory disorder; MR-guided focused ultrasound; neurologic examination; neuromodulation; neuronavigation; nuclear magnetic resonance imaging; outcome assessment; pilot study; prospective study; seizure; spectroscopy; stereoelectroencephalography; treatment planning; video surveillance; animal; diagnostic imaging; drug resistant epilepsy; electroencephalography; epilepsy; procedures; seizure; Animals; Drug Resistant Epilepsy; Electroencephalography; Epilepsy; Humans; Pilot Projects; Seizures |
顯示於: | 電機工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。