https://scholars.lib.ntu.edu.tw/handle/123456789/607265
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kao Y.-C | en_US |
dc.contributor.author | Chen Z.-H | en_US |
dc.contributor.author | Wang W.-Y | en_US |
dc.contributor.author | Lee C.-H | en_US |
dc.contributor.author | PO-LING KUO | - |
dc.creator | Kao Y.-C;Chen Z.-H;Wang W.-Y;Lee C.-H;Kuo P.-L. | - |
dc.date.accessioned | 2022-04-25T06:43:01Z | - |
dc.date.available | 2022-04-25T06:43:01Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0006291X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108441826&doi=10.1016%2fj.bbrc.2021.06.055&partnerID=40&md5=1fedc877a47e42317d37338cd6838596 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/607265 | - |
dc.description.abstract | Fibroblast migration is closely regulated by the mechanical characteristics in surrounding microenvironment. While increased interstitial hydrostatic pressure (HP) is a hallmark in many pathological and physiological conditions, little is known about how the HP affects fibroblast motility. Using cell-culture chips with elevated HP conditions, we showed that 20 cmH2O HP significantly accelerated fibroblast migration. The HP-induced migration acceleration was dependent on the augmentation of transforming growth factor-β1, and correlated with the activation of filamin A via the phosphorylation of p38 mitogen-activated protein kinase. Our results suggest that interstitial HP elevation associated with various pathological states could significantly regulate fibroblast migration. ? 2021 The Authors | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject | Cell motility | - |
dc.subject | Fibroblast | - |
dc.subject | Filamin | - |
dc.subject | Interstitial hydrostatic pressure | - |
dc.subject | p38 | - |
dc.subject | TGF-β | - |
dc.subject | filamin A | - |
dc.subject | mitogen activated protein kinase p38 | - |
dc.subject | transforming growth factor beta | - |
dc.subject | filamin | - |
dc.subject | FlnA protein, mouse | - |
dc.subject | Article | - |
dc.subject | cell culture | - |
dc.subject | cell migration | - |
dc.subject | cell motility | - |
dc.subject | controlled study | - |
dc.subject | fibroblast | - |
dc.subject | hydrostatic pressure | - |
dc.subject | MAPK signaling | - |
dc.subject | NIH 3T3 cell line | - |
dc.subject | protein expression | - |
dc.subject | protein function | - |
dc.subject | protein phosphorylation | - |
dc.subject | protein secretion | - |
dc.subject | upregulation | - |
dc.subject | animal | - |
dc.subject | cell motion | - |
dc.subject | cytology | - |
dc.subject | metabolism | - |
dc.subject | mouse | - |
dc.subject | phosphorylation | - |
dc.subject | Animals | - |
dc.subject | Cell Movement | - |
dc.subject | Fibroblasts | - |
dc.subject | Filamins | - |
dc.subject | Hydrostatic Pressure | - |
dc.subject | Mice | - |
dc.subject | NIH 3T3 Cells | - |
dc.subject | p38 Mitogen-Activated Protein Kinases | - |
dc.subject | Phosphorylation | - |
dc.subject | Transforming Growth Factor beta | - |
dc.title | Hydrostatic pressure promotes migration and filamin-A activation in fibroblasts with increased p38 phosphorylation and TGF-β production | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.bbrc.2021.06.055 | - |
dc.identifier.pmid | 34174537 | - |
dc.identifier.scopus | 2-s2.0-85108441826 | - |
dc.relation.pages | 15-22 | - |
dc.relation.journalvolume | 568 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 電機工程學系 |
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