https://scholars.lib.ntu.edu.tw/handle/123456789/621244
標題: | Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes | 作者: | Tsai, Ya-Chu TSEN-FANG TSAI |
關鍵字: | atopic dermatitis; concomitant; overlap; paradoxical; psoriasis; psoriasis dermatitis | 公開日期: | 15-五月-2022 | 出版社: | MDPI | 卷: | 23 | 期: | 10 | 來源出版物: | International journal of molecular sciences | 摘要: | Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both diseases were noted in some populations, including Chinese. Shared immunopathogenesis involving Th17, Th1, Th22 cells, or even IL-13 was found in certain stages or phenotypes. This review discusses the overlapping genetic susceptibility, shared cytokines, immune-mediated comorbidities, and clinical presentations. Overlapping conditions could be classified into mainly PSO lesions with AD features or vice versa, concomitant PSO and AD, or disease transformation as a result of biologics treatment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/621244 | ISSN: | 16616596 | DOI: | 10.3390/ijms23105518 |
顯示於: | 醫學系 |
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