Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes
Journal
International journal of molecular sciences
Journal Volume
23
Journal Issue
10
Date Issued
2022-05-15
Author(s)
Tsai, Ya-Chu
Abstract
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both diseases were noted in some populations, including Chinese. Shared immunopathogenesis involving Th17, Th1, Th22 cells, or even IL-13 was found in certain stages or phenotypes. This review discusses the overlapping genetic susceptibility, shared cytokines, immune-mediated comorbidities, and clinical presentations. Overlapping conditions could be classified into mainly PSO lesions with AD features or vice versa, concomitant PSO and AD, or disease transformation as a result of biologics treatment.
Subjects
atopic dermatitis; concomitant; overlap; paradoxical; psoriasis; psoriasis dermatitis
SDGs
Publisher
MDPI
Type
review