https://scholars.lib.ntu.edu.tw/handle/123456789/623063
Title: | Pulsatilla decoction suppresses matrix metalloproteinase-7-mediated leukocyte recruitment in dextran sulfate sodium-induced colitis mouse model | Authors: | Lin, Ming-Kuem Yang, Ya-Ting Lin, Li-Jen WEI-HSUAN YU Chen, Huan-Yuan |
Keywords: | Intestinal inflammation; Leukocyte recruitment; Matrix metalloproteinase-7; Pulsatilla decoction; Ulcerative colitis | Issue Date: | 6-Aug-2022 | Publisher: | BMC | Journal Volume: | 22 | Journal Issue: | 1 | Source: | BMC complementary medicine and therapies | Abstract: | Intestinal inflammation is considered to be an important characteristic of ulcerative colitis (UC) and the current medical treatments for UC are usually proposed to suppress abnormal intestinal immune responses. Pulsatilla decoction (PD), a traditional Chinese medicine, is frequently used in UC treatments in Asian countries; however, the mechanism of the action of PD remains unclear. In the present study, the mechanism of the action of PD was elucidated in the dextran sulfate sodium (DSS)-induced colitis mouse model, a model to mimic UC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/623063 | ISSN: | 2662-7671 | DOI: | 10.1186/s12906-022-03696-w |
Appears in Collections: | 生物化學暨分子生物學科研究所 |
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