https://scholars.lib.ntu.edu.tw/handle/123456789/626472
標題: | Chemical constituents and their anti-neuroinflammatory activities from the bark of Taiwan incense cedar, Calocedrus formosana | 作者: | Wu, Ho-Cheng Chen, Yu-Chang Hsieh, Chin-Lin Hsiao, George Wang, Shih-Wei Cheng, Ming-Jen Chao, Che-Yi TZONG-HUEI LEE Kuo, Yueh-Hsiung |
關鍵字: | Anti-inflammatory activity; BV-2 microglial cells; Calocedrus formosana; Cupressaceae; Diterpenes; Taiwan incense cedar; Tetraterpene | 公開日期: | 24-八月-2022 | 出版社: | PERGAMON-ELSEVIER SCIENCE LTD | 卷: | 204 | 期: | 113347 | 來源出版物: | Phytochemistry | 摘要: | One undescribed C40 terpenoid, calomacroquinoic acid; four undescribed diterpenes, 5α,6α-epoxy-7α-hydroxyferruginol, 15-ethoxysugiol, 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol, and ethyl 7,8-secoabieta-11,14-dioxo-7-ate; two compounds isolated from Nature for the first time, 6β,7α-dihydroxyferruginol and 12-O-methyltaxochinon; and six known compounds were successfully identified from the bark of Taiwan incense cedar Calocedrus formosana. Structures of all isolates were elucidated by physical data (appearance, ultraviolet, infrared, specific rotation, and X-ray) and spectroscopic data (1D and 2D nuclear magnetic resonance, and high-resolution electron ionization mass spectrometry). The biosynthetic pathway of calomacroquinoic acid is also described in the current study. Nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells was inhibited by 6,7-dehydroferruginol, 7α,11-dihydroxy-12-methoxy-8,11,13-abietriene, and trans-communic acid. Altogether, the bark of C. formosana possessed several potential natural therapeutics against inflammation-related neuronal diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626472 | ISSN: | 0031-9422 | DOI: | 10.1016/j.phytochem.2022.113347 |
顯示於: | 漁業科學研究所 |
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