https://scholars.lib.ntu.edu.tw/handle/123456789/627090
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Li, Shiming | en_US |
dc.contributor.author | Lin, Yi-Chin | en_US |
dc.contributor.author | Ho, Chi-Tang | en_US |
dc.contributor.author | Lin, Ping-Yi | en_US |
dc.contributor.author | Suzawa, Michiko | en_US |
dc.contributor.author | Wang, Hsin-Chieh | en_US |
dc.contributor.author | CHING-LIANG CHU | en_US |
dc.contributor.author | Chen, Der-Yuan | en_US |
dc.contributor.author | LIN-CHI CHEN | en_US |
dc.date.accessioned | 2023-01-10T03:00:37Z | - |
dc.date.available | 2023-01-10T03:00:37Z | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/627090 | - |
dc.description.abstract | It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | International Immunopharmacology | en_US |
dc.subject | Citrus; Contact hypersensitivity (CHS); Dendritic cells; Peels; T cells | en_US |
dc.title | Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.intimp.2014.02.005 | - |
dc.identifier.pmid | 24566093 | - |
dc.identifier.scopus | 2-s2.0-84895535344 | - |
dc.identifier.isi | WOS:000336337900002 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/384210 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-84895535344&partnerID=MN8TOARS | - |
dc.relation.pages | 12 | en_US |
dc.relation.journalvolume | 20 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pageend | 23 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Immunology | - |
crisitem.author.dept | Biomechatronics Engineering | - |
crisitem.author.dept | Office of Academic Affairs | - |
crisitem.author.dept | Others: Center for General Education | - |
crisitem.author.orcid | 0000-0002-8463-526X | - |
crisitem.author.orcid | 0000-0001-5947-2019 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | National Taiwan University | - |
顯示於: | 免疫學研究所 |
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