https://scholars.lib.ntu.edu.tw/handle/123456789/627090
Title: | Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity | Authors: | Li, Shiming Lin, Yi-Chin Ho, Chi-Tang Lin, Ping-Yi Suzawa, Michiko Wang, Hsin-Chieh CHING-LIANG CHU Chen, Der-Yuan LIN-CHI CHEN |
Keywords: | Citrus; Contact hypersensitivity (CHS); Dendritic cells; Peels; T cells | Issue Date: | May-2014 | Publisher: | ELSEVIER | Journal Volume: | 20 | Journal Issue: | 1 | Start page/Pages: | 12 | Source: | International Immunopharmacology | Abstract: | It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627090 | ISSN: | 1567-5769 | DOI: | 10.1016/j.intimp.2014.02.005 |
Appears in Collections: | 免疫學研究所 |
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