https://scholars.lib.ntu.edu.tw/handle/123456789/627896
標題: | Dual-tracer positron emission tomography/computed tomography as an imaging probe of de novo lipogenesis in preclinical models of hepatocellular carcinoma | 作者: | Tsao, Chin-Ho Jhou, Rong-Hong Ke, Chien-Chih CHUN-WEI CHANG Chang, Chi-Wei Yang, Bang-Hung Huang, Wen-Sheng Shih, Bing-Fu Liu, Ren-Shyan |
關鍵字: | PET/CT; cancer metabolism; cancer therapy; de novo lipogenesis; hepatocellular carcinoma; imaging probe; lipogenesis-targeted therapy | 公開日期: | 27-九月-2022 | 出版社: | FRONTIERS MEDIA SA | 卷: | 9 | 來源出版物: | Frontiers in medicine | 摘要: | De novo lipogenesis is upregulated in many cancers, and targeting it represents a metabolic approach to cancer treatment. However, the treatment response is unpredictable because lipogenic activity varies greatly among individual tumors, thereby necessitating the assessment of lipogenic activity before treatment. Here, we proposed an imaging probe, positron emission tomography/computed tomography (PET/CT) with dual tracers combining 11C-acetate and 18F-fluorodeoxyglucose (18F-FDG), to assess the lipogenic activity of hepatocellular carcinoma (HCC) and predict the response to lipogenesis-targeted therapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627896 | ISSN: | 2296-858X | DOI: | 10.3389/fmed.2022.1008200 |
顯示於: | 漁業科學研究所 |
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