Dual-tracer positron emission tomography/computed tomography as an imaging probe of de novo lipogenesis in preclinical models of hepatocellular carcinoma
Journal
Frontiers in medicine
Journal Volume
9
Date Issued
2022-09-27
Author(s)
Tsao, Chin-Ho
Jhou, Rong-Hong
Ke, Chien-Chih
Chang, Chi-Wei
Yang, Bang-Hung
Huang, Wen-Sheng
Shih, Bing-Fu
Liu, Ren-Shyan
Abstract
De novo lipogenesis is upregulated in many cancers, and targeting it represents a metabolic approach to cancer treatment. However, the treatment response is unpredictable because lipogenic activity varies greatly among individual tumors, thereby necessitating the assessment of lipogenic activity before treatment. Here, we proposed an imaging probe, positron emission tomography/computed tomography (PET/CT) with dual tracers combining 11C-acetate and 18F-fluorodeoxyglucose (18F-FDG), to assess the lipogenic activity of hepatocellular carcinoma (HCC) and predict the response to lipogenesis-targeted therapy.
Subjects
PET/CT; cancer metabolism; cancer therapy; de novo lipogenesis; hepatocellular carcinoma; imaging probe; lipogenesis-targeted therapy
Publisher
FRONTIERS MEDIA SA
Type
journal article