https://scholars.lib.ntu.edu.tw/handle/123456789/629364
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang, Shu-Jyuan | en_US |
dc.contributor.author | Pai, Jui-An | en_US |
dc.contributor.author | Yao, Cheng-Jung | en_US |
dc.contributor.author | Huang, Chung-Huan | en_US |
dc.contributor.author | JENNY LING-YU CHEN | en_US |
dc.contributor.author | Ching-Hua Wang | en_US |
dc.contributor.author | KE-CHENG CHEN | en_US |
dc.contributor.author | MING-JIUM SHIEH | en_US |
dc.date.accessioned | 2023-03-17T06:47:42Z | - |
dc.date.available | 2023-03-17T06:47:42Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1868-6958 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/629364 | - |
dc.description.abstract | Background: Chemo-radiotherapy is the combined chemotherapy and radiotherapy on tumor treatment to obtain the local radiosensitization and local cytotoxicity of the tumor and to control the microscopic metastatic disease. Methods: In this study, 7-ethyl-10-hydroxycamptothecin (SN38) molecules could be successfully loaded into human serum albumin (HSA)–hyaluronic acid (HA) nanoparticles (SH/HA NPs) by the hydrophobic side groups of amino acid in HSA. Results: HSA could be used to increase the biocompatibility and residence time of the nanoparticles in the blood, whereas HA could improve the benefits and overall treatment effect on CD44-expressing colorectal cancer (CRC), and reduce drug side effects. In addition to its role as a chemotherapeutic agent, SN38 could be used as a radiosensitizer, able to arrest the cell cycle, and allowing cells to stay in the G2/M stage, to improve the sensitivity of tumor cells to radiation. In vivo results demonstrated that SH/HA NPs could accumulate in the tumor and produce significant tumor suppression, with no adverse effects observed when combined with γ-ray irradiation. This SH/HA NPs-medicated chemo-radiotherapy could induce an anti-tumor immune response to inhibit the growth of distal tumors, and produce an abscopal effect. Conclusions: Therefore, this SN38-loaded and HA-incorporated nanoparticle combined with radiotherapy may be a promising therapeutic artifice for CRC in the future. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartof | CANCER NANOTECHNOLOGY | en_US |
dc.subject | Chemo-radiotherapy; 7-Ethyl-10-hydroxycamptothecin; Human serum albumin; Hyaluronic acid; Abscopal effect; DRUG-DELIVERY; ENHANCED PERMEABILITY; ALBUMIN NANOPARTICLES; OXIDE NANOPARTICLES; CELLS; SENSITIVITY; IRINOTECAN; PRODRUG; KINASE; CPT-11 | en_US |
dc.title | SN38-loaded nanomedicine mediates chemo-radiotherapy against CD44-expressing cancer growth | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/s12645-022-00151-w | - |
dc.identifier.scopus | 2-s2.0-85145461927 | - |
dc.identifier.isi | WOS:000906713100001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85145461927 | - |
dc.relation.journalvolume | 14 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.orcid | 0000-0001-8553-8069 | - |
crisitem.author.orcid | 0000-0001-6330-0674 | - |
crisitem.author.orcid | 0000-0003-2921-4443 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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