https://scholars.lib.ntu.edu.tw/handle/123456789/629364
Title: | SN38-loaded nanomedicine mediates chemo-radiotherapy against CD44-expressing cancer growth | Authors: | Yang, Shu-Jyuan Pai, Jui-An Yao, Cheng-Jung Huang, Chung-Huan JENNY LING-YU CHEN Ching-Hua Wang KE-CHENG CHEN MING-JIUM SHIEH |
Keywords: | Chemo-radiotherapy; 7-Ethyl-10-hydroxycamptothecin; Human serum albumin; Hyaluronic acid; Abscopal effect; DRUG-DELIVERY; ENHANCED PERMEABILITY; ALBUMIN NANOPARTICLES; OXIDE NANOPARTICLES; CELLS; SENSITIVITY; IRINOTECAN; PRODRUG; KINASE; CPT-11 | Issue Date: | 2023 | Publisher: | BMC | Journal Volume: | 14 | Journal Issue: | 1 | Source: | CANCER NANOTECHNOLOGY | Abstract: | Background: Chemo-radiotherapy is the combined chemotherapy and radiotherapy on tumor treatment to obtain the local radiosensitization and local cytotoxicity of the tumor and to control the microscopic metastatic disease. Methods: In this study, 7-ethyl-10-hydroxycamptothecin (SN38) molecules could be successfully loaded into human serum albumin (HSA)–hyaluronic acid (HA) nanoparticles (SH/HA NPs) by the hydrophobic side groups of amino acid in HSA. Results: HSA could be used to increase the biocompatibility and residence time of the nanoparticles in the blood, whereas HA could improve the benefits and overall treatment effect on CD44-expressing colorectal cancer (CRC), and reduce drug side effects. In addition to its role as a chemotherapeutic agent, SN38 could be used as a radiosensitizer, able to arrest the cell cycle, and allowing cells to stay in the G2/M stage, to improve the sensitivity of tumor cells to radiation. In vivo results demonstrated that SH/HA NPs could accumulate in the tumor and produce significant tumor suppression, with no adverse effects observed when combined with γ-ray irradiation. This SH/HA NPs-medicated chemo-radiotherapy could induce an anti-tumor immune response to inhibit the growth of distal tumors, and produce an abscopal effect. Conclusions: Therefore, this SN38-loaded and HA-incorporated nanoparticle combined with radiotherapy may be a promising therapeutic artifice for CRC in the future. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629364 | ISSN: | 1868-6958 | DOI: | 10.1186/s12645-022-00151-w |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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