https://scholars.lib.ntu.edu.tw/handle/123456789/629573
Title: | Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases | Authors: | Chatziioannou, Aristotelis Georgiadis, Panagiotis Hebels, Dennie G. Liampa, Irene Valavanis, Ioannis Bergdahl, Ingvar A. Johansson, Anders Palli, Domenico Chadeau-Hyam, Marc Siskos, Alexandros P. Keun, Hector Botsivali, Maria De Kok, Theo M.C.M. Pérez, Almudena Espín Kleinjans, Jos C.S. Vineis, Paolo Kyrtopoulos, Soterios A. Gottschalk, Ralph Van Leeuwen, Danitsja Timmermans, Leen Bendinelli, Benedetta Kelly, Rachel Vermeulen, Roel Portengen, Lutzen Saberi-Hosnijeh, Fatemeh Melin, Beatrice Hallmans, Goran Lenner, Per Athersuch, Toby J. Kogevinas, Manolis Stephanou, Euripides G. Myridakis, Antonis Fazzo, Lucia De Santis, Marco Comba, Pietro Kiviranta, Hannu Rantakokko, Panu Airaksinen, Riikka Ruokojarvi, Paivi Gilthorpe, Mark Fleming, Sarah Fleming, Thomas YU-KANG TU Jonsson, Bo Lundh, Thomas WEI J. CHEN WEN-CHUNG LEE CHUHSING KATE HSIAO KUO-LIONG CHIEN PO-HSIU KUO HUNG HUNG Liao, Shu Fen |
Keywords: | SEX-DIFFERENCES; LUNG-CANCER; GENE-EXPRESSION; CIGARETTE-SMOKING; HEME OXYGENASE-1; RISK-FACTOR; PLATELET; WOMEN; MEN; METAANALYSIS | Issue Date: | 22-Feb-2017 | Publisher: | NATURE PUBLISHING GROUP | Journal Volume: | 7 | Journal Issue: | 1 | Source: | Scientific Reports | Abstract: | We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629573 | ISSN: | 2045-2322 | DOI: | 10.1038/srep42870 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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