https://scholars.lib.ntu.edu.tw/handle/123456789/629678
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang, Bo | en_US |
dc.contributor.author | Tseng, Ping-Tao | en_US |
dc.contributor.author | Hu, Xiang | en_US |
dc.contributor.author | Zeng, Bing-Yan | en_US |
dc.contributor.author | Chang, Jane Pei-Chen | en_US |
dc.contributor.author | Liu, Yang | en_US |
dc.contributor.author | Chu, Wei-Jie | en_US |
dc.contributor.author | Zhang, Shuang-Shuang | en_US |
dc.contributor.author | Zhou, Zhi-Liang | en_US |
dc.contributor.author | Chu, Chih-Sheng | en_US |
dc.contributor.author | Chang, Cheng-Ho | en_US |
dc.contributor.author | YU-KANG TU | en_US |
dc.contributor.author | Wu, Yi-Cheng | en_US |
dc.contributor.author | Stubbs, Brendon | en_US |
dc.contributor.author | Carvalho, Andre F | en_US |
dc.contributor.author | Lin, Pao-Yen | en_US |
dc.contributor.author | Matsuoka, Yutaka J | en_US |
dc.contributor.author | Suen, Mein-Woei | en_US |
dc.contributor.author | Su, Kuan-Pin | en_US |
dc.date.accessioned | 2023-03-25T06:33:28Z | - |
dc.date.available | 2023-03-25T06:33:28Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 0163-7827 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/629678 | - |
dc.description.abstract | The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials (RCTs). Here we conducted a comprehensive narrative review of pre-clinical studies and updated a network meta-analysis (NMA) to determine the comparative efficacy against MCE with different EPA/DHA dosages and formulas. We found that pure EPA was ranked the best option in the secondary prevention (hazard ratio: 0.72, 95% confidence interval: 0.65 to 0.81) from the NMA of 39 RCTs with 88,359 participants. There was no evidence of omega-3 PUFAs' efficacy in primary prevention. The mechanisms of omega-3 PUFAs' cardiovascular protection might link to the effects of anti-inflammation and stabilization of endothelial function from PUFA's derivatives including eicosanoids and the special pre-resolving mediators (SPMs). | en_US |
dc.language.iso | en | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.ispartof | Progress In Lipid Research | en_US |
dc.subject | Cardiovascular disease; Major cardiovascular events; Network meta-analysis; Omega-3 | en_US |
dc.title | Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials | en_US |
dc.type | journal article | en |
dc.type | review | en_US |
dc.identifier.doi | 10.1016/j.plipres.2022.101196 | - |
dc.identifier.pmid | 36341839 | - |
dc.identifier.scopus | 2-s2.0-85141320763 | - |
dc.identifier.isi | WOS:000899624100001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85141320763 | - |
dc.relation.journalvolume | 88 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Master of Public Health Degree Program | - |
crisitem.author.orcid | 0000-0002-2461-474X | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
顯示於: | 流行病學與預防醫學研究所 |
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