https://scholars.lib.ntu.edu.tw/handle/123456789/629678
Title: | Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials | Authors: | Yang, Bo Tseng, Ping-Tao Hu, Xiang Zeng, Bing-Yan Chang, Jane Pei-Chen Liu, Yang Chu, Wei-Jie Zhang, Shuang-Shuang Zhou, Zhi-Liang Chu, Chih-Sheng Chang, Cheng-Ho YU-KANG TU Wu, Yi-Cheng Stubbs, Brendon Carvalho, Andre F Lin, Pao-Yen Matsuoka, Yutaka J Suen, Mein-Woei Su, Kuan-Pin |
Keywords: | Cardiovascular disease; Major cardiovascular events; Network meta-analysis; Omega-3 | Issue Date: | Nov-2022 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Journal Volume: | 88 | Source: | Progress In Lipid Research | Abstract: | The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials (RCTs). Here we conducted a comprehensive narrative review of pre-clinical studies and updated a network meta-analysis (NMA) to determine the comparative efficacy against MCE with different EPA/DHA dosages and formulas. We found that pure EPA was ranked the best option in the secondary prevention (hazard ratio: 0.72, 95% confidence interval: 0.65 to 0.81) from the NMA of 39 RCTs with 88,359 participants. There was no evidence of omega-3 PUFAs' efficacy in primary prevention. The mechanisms of omega-3 PUFAs' cardiovascular protection might link to the effects of anti-inflammation and stabilization of endothelial function from PUFA's derivatives including eicosanoids and the special pre-resolving mediators (SPMs). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629678 | ISSN: | 0163-7827 | DOI: | 10.1016/j.plipres.2022.101196 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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