https://scholars.lib.ntu.edu.tw/handle/123456789/630655
標題: | Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice | 作者: | Dalaijamts, Chimeddulam Cichocki, Joseph A YU-SYUAN LUO Rusyn, Ivan Chiu, Weihsueh A |
關鍵字: | Bayesian analysis; Glutathione conjugation; Oxidative metabolism; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; Tetrachloroethylene | 公開日期: | 1-八月-2018 | 出版社: | ACADEMIC PRESS INC ELSEVIER SCIENCE | 卷: | 352 | 起(迄)頁: | 142 | 來源出版物: | Toxicology and applied pharmacology | 摘要: | Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways. Previous physiologically-based pharmacokinetic (PBPK) modeling of perc accurately predicted oxidative metabolites but suggested the need to better characterize glutathione (GSH) conjugation as well as toxicokinetic uncertainty and variability. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630655 | ISSN: | 0041-008X | DOI: | 10.1016/j.taap.2018.05.033 |
顯示於: | 食品安全與健康研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。