Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice
Journal
Toxicology and applied pharmacology
Journal Volume
352
Pages
142
Date Issued
2018-08-01
Author(s)
Abstract
Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways. Previous physiologically-based pharmacokinetic (PBPK) modeling of perc accurately predicted oxidative metabolites but suggested the need to better characterize glutathione (GSH) conjugation as well as toxicokinetic uncertainty and variability.
Subjects
Bayesian analysis; Glutathione conjugation; Oxidative metabolism; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; Tetrachloroethylene
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Type
journal article