https://scholars.lib.ntu.edu.tw/handle/123456789/633497
Title: | Estimating arsenic biotransfer factors from feed to chicken: a viable approach to animal feed risk assessment | Authors: | Hung, Ching Chi Lin, Hsin Tang CHING-YI CHEN Chen, Kuan Yi Lee, Tsung Yu Chiang, Chow Feng |
Keywords: | Arsenic | biotransfer factor | chicken-feed risk assessment | human exposure assessment | Monte Carlo simulation | Issue Date: | 1-Jan-2023 | Source: | Food Additives and Contaminants - Part A | Abstract: | Reliable biotransfer factor (BTF) data are critical for animal-feed studies in human risk assessment. A wide range of BTF values have been reported (0.0015–0.83 d/kg), expressed as the ratio of total arsenic (tAs) concentration (µg/kg) in chicken to daily intake rate (µg/d) of tAs in feed (tAs/tAs). Data on inorganic As (iAs) for chicken meat and tAs concentrations for feed were obtained from our related study. Using the linear regression technique developed in this study, we estimated the BTF as 0.016 d/kg, as iAs/tAs (R 2 > 0.7702) and 0.55 d/kg as tAs/tAs (R 2 = 0.9743) for whole chicken meat. From a mass-balance perspective, we suggest that tAs be used as the denominator for the BTF unit. To illustrate our feed-risk assessment method, we analyzed commercial feeds for tAs concentration (n = 79). Consumption data for the general population (n = 2479) were obtained from a Taiwanese total diet study. Bivariate Monte Carlo simulations (n = 10,000) showed that the 95th percentile (P95) of estimated daily intake (EDI) was 0.002 µg/kg body weight (bw)/d as iAs (< the benchmark dose lower limit of 3.0 µg/kg bw/d). Our results thus show that the commercial chicken feeds assessed in this study are of low health concern for the general Taiwanese population. We discuss the factors that may have affected the assessment, such as the type of animals investigated, type of feeds, feed tested, type of chemical species used for BTF estimation and statistical approach. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161801264&doi=10.1080%2f19440049.2023.2220413&partnerID=40&md5=3c03fc89511be254b17dd2533f2d8475 https://scholars.lib.ntu.edu.tw/handle/123456789/633497 |
ISSN: | 19440049 | DOI: | 10.1080/19440049.2023.2220413 |
Appears in Collections: | 動物科學技術學系 |
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