https://scholars.lib.ntu.edu.tw/handle/123456789/635378
Title: | A population-based cohort study of the epidemiology of light-chain amyloidosis in Taiwan | Authors: | HSIN-AN HOU Tang, Chao-Hsiun Goh, Choo Hua Shen, Shih-Pei KUAN-CHIH HUANG Qiu, Hong Siggins, Sarah Rothwell, Lee Anne Liu, Yanfang |
Issue Date: | 21-Sep-2022 | Journal Volume: | 12 | Journal Issue: | 1 | Start page/Pages: | 15736 | Source: | Scientific reports | Abstract: | The incidence rate of AL (light-chain) amyloidosis is not known in Asia. We conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database and Death Registry to estimate incidence and all-cause case fatality rates, and characteristics of patients with AL amyloidosis in Taiwan. All patients with confirmed, newly diagnosed AL amyloidosis from 01-Jan-2016 until 31-Dec-2019 were enrolled and followed up until dis-enrolment, death or study end (31-Dec-2019). There were 841 patients with newly diagnosed AL amyloidosis with median age of 61.4 years and 58.7% were men. At diagnosis, cardiac, renal and liver-related diseases were present in 28.54%, 23.19% and 2.14% of patients, respectively. AL amyloidosis age-adjusted annual incidence was 5.73 per million population in 2016 and 5.26 per million population in 2019. All-cause case fatality ranged from 1.7 to 2.9% over the study period and was highest (~10%) in patients ≥ 80 years. Survival was significantly lower in patients with co-morbid cardiac, renal, or liver-related diseases which could indicate organ involvement. The incidence of AL amyloidosis in Taiwan appears to be similar to Western countries. The poor prognosis in patients with co-morbid diseases highlights the need for earlier diagnosis. |
URI: | https://pubmed.ncbi.nlm.nih.gov/36131079/ https://scholars.lib.ntu.edu.tw/handle/123456789/635378 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-18990-3 |
Appears in Collections: | 醫學系 |
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