https://scholars.lib.ntu.edu.tw/handle/123456789/635380
標題: | SURPASS-ET: phase III study of ropeginterferon alfa-2b versus anagrelide as second-line therapy in essential thrombocythemia | 作者: | Verstovsek, Srdan Komatsu, Norio Gill, Harinder Jin, Jie Lee, Sung-Eun HSIN-AN HOU Sato, Toshiaki Qin, Albert Urbanski, Raymond Shih, Weichung Zagrijtschuk, Oleh Zimmerman, Craig Mesa, Ruben A |
關鍵字: | P1101; SURPASS-ET; anagrelide; essential thrombocythemia; hydroxyurea; interferon; myeloproliferative neoplasm; pegylated interferon; ropeginterferon alfa-2b | 公開日期: | 九月-2022 | 卷: | 18 | 期: | 27 | 起(迄)頁: | 2999 | 來源出版物: | Future oncology (London, England) | 摘要: | Patients diagnosed with high-risk essential thrombocythemia (ET) have limited treatment options to reduce the risk of thrombosis and lessen the progression of the disease by targeting the molecular source. Hydroxyurea is the recommended treatment, but many patients experience resistance or intolerance. Anagrelide is an approved second-line option for ET, but concerns of a higher frequency of disease transformation may affect its role as a suitable long-term option. Interferons have been evaluated in myeloproliferative neoplasms for over 30 years, but early formulations had safety and tolerability issues. SURPASS-ET (NCT04285086) is a phase III, open-label, multicenter, global, randomized, active-controlled trial that will evaluate the safety, efficacy, tolerability and pharmacokinetics of ropeginterferon alfa-2b compared with anagrelide as second-line therapy in high-risk ET. |
URI: | https://pubmed.ncbi.nlm.nih.gov/35924546/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138514378&doi=10.2217%2ffon-2022-0596&partnerID=40&md5=ca7fa0816ff0b345ec3427f64c82bb8f https://scholars.lib.ntu.edu.tw/handle/123456789/635380 |
ISSN: | 14796694 | DOI: | 10.2217/fon-2022-0596 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。