https://scholars.lib.ntu.edu.tw/handle/123456789/635936
標題: | Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis | 作者: | Zou, Yiyu Tsai, Wen-Bin Cheng, Chien-Jui CHIUN HSU Chung, Young Min Li, Pao-Chen Lin, Sue-Hwa Hu, Mickey C T |
公開日期: | 2008 | 卷: | 10 | 期: | 1 | 來源出版物: | Breast cancer research : BCR | 摘要: | Estrogen receptors (ERs) play key roles in breast cancer development and influence treatment outcome in breast cancer patients. Identification of molecules that regulate ER function may facilitate development of breast cancer treatment strategies. The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to function as a tumor suppressor in breast cancer. Using protein-protein interaction screening, we found that FOXO3a interacted with ER-alpha and ER-beta proteins in the human breast carcinoma cell line MCF-7, suggesting that there exists a crosstalk between the FOXO3a and ER signaling pathways in estrogen-dependent breast cancer cells. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635936 | ISSN: | 14655411 | DOI: | 10.1186/bcr1872 |
顯示於: | 腫瘤醫學研究所 |
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