|Title:||Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis||Authors:||Zou, Yiyu
Chung, Young Min
Hu, Mickey C T
|Issue Date:||2008||Journal Volume:||10||Journal Issue:||1||Source:||Breast cancer research : BCR||Abstract:||
Estrogen receptors (ERs) play key roles in breast cancer development and influence treatment outcome in breast cancer patients. Identification of molecules that regulate ER function may facilitate development of breast cancer treatment strategies. The forkhead box class O (FOXO) transcription factor FOXO3a has been suggested to function as a tumor suppressor in breast cancer. Using protein-protein interaction screening, we found that FOXO3a interacted with ER-alpha and ER-beta proteins in the human breast carcinoma cell line MCF-7, suggesting that there exists a crosstalk between the FOXO3a and ER signaling pathways in estrogen-dependent breast cancer cells.
|Appears in Collections:||腫瘤醫學研究所|
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