https://scholars.lib.ntu.edu.tw/handle/123456789/638122
標題: | A functional chicken-liver hydrolysate-based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti-inflammation, and antiapoptosis | 作者: | Wu, Yi Hsieng Samuel Lin, Yi Ling Kao, Yi Feng Chen, Jr Wei Chen, Yi Chou YI-CHEN CHEN |
關鍵字: | alcohol metabolism | anti-inflammatory response | antiapoptosis | antioxidant capacity | chicken-liver hydrolysate-based supplement | 公開日期: | 三月-2024 | 卷: | 39 | 期: | 3 | 起(迄)頁: | 1759 - 1768 | 來源出版物: | Environmental Toxicology | 摘要: | Tons of broiler livers are produced yearly in Taiwan but always considered waste. Our team has successfully patented and characterized a chicken-liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH-based supplement (GBHP01™) against chronic alcohol consumption. Results showed that GBHP01™ could reduce (p <.05) enlarged liver size, lipid accumulation/steatosis scores, and higher serum AST, ALT, γ-GT, triglyceride, and cholesterol levels induced by an alcoholic liquid diet. GBHP01™ reduced liver inflammation and apoptosis in alcoholic liquid-diet-fed mice via decreasing TBARS, interleukin-6, interleukin-1β, and tumor necrosis factor-α levels, increasing reduced GSH/TEAC levels and activities of SOD, CAT and GPx, as well as downregulating CYP2E1, BAX/BCL2, Cleaved CASPASE-9/Total CASPASE-9 and Active CASPASE-3/Pro-CASPASE-3 (p <.05). Furthermore, GBHP01™ elevated hepatic alcohol metabolism (ADH and ALDH activities) (p <.05). In conclusion, this study prove the hepatoprotection of GBHP01™ against alcohol consumption. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85178418508&origin=resultslist https://scholars.lib.ntu.edu.tw/handle/123456789/638122 |
ISSN: | 15204081 | DOI: | 10.1002/tox.24072 |
顯示於: | 動物科學技術學系 |
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