https://scholars.lib.ntu.edu.tw/handle/123456789/638325
Title: | Conversion of 5-iodo-2-pyrimidinone-2'-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design | Authors: | Chien-Neng, Chang SHIN-LIAN DOONG Yung-Chi, Cheng |
Issue Date: | 28-May-1992 | Journal Volume: | 43 | Journal Issue: | 10 | Source: | Biochemical Pharmacology | Abstract: | 5-Iodo-2-pyrimidinone-2'-deoxyribose (IPdR) can be converted into 5-iodo-deoxyuridine (IUdR), a clinical radiosensitizer, by aldehyde oxidase in the liver. This conversion does not require exogenous cofactors and cannot be catalyzed by mixed-function oxidases, xanthine oxidase or many other oxido-reductases. This "IPdR oxidase" activity is enriched in the liver; thus, extensive conversion of IPdR to IUdR could be anticipated in the liver and the therapeutic index of IPdR could be better than that of IUdR as a radiosensitizer for primary liver cancers or tumors metastasized to the liver. Based on structure and activity relationship studies, nucleoside analogues which could be activated by this enzyme to compounds capable of inhibiting DNA synthesis could be designed and should be explored as agents against cancer, viruses or parasites in the liver. © 1992. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638325 | ISSN: | 00062952 | DOI: | 10.1016/0006-2952(92)90186-M |
Appears in Collections: | 微生物學科所 |
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