https://scholars.lib.ntu.edu.tw/handle/123456789/639010
Title: | Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells | Authors: | Chang, Charn-Jung Chiang, Chih-Hung Song, Wen-Shin Tsai, Shen-Kou LIN-CHUNG WOUNG Chang, Chin-Hong Jeng, Shaw-Yeu Tsai, Ching-Yao Hsu, Chuan-Chih Lee, Hung-Fu Huang, Chi-Shuan Yung, Ming-Chi Liu, Jorn-Hon Lu, Kai-Hsi |
Keywords: | Cancer stem cells | CD133 | Cucurbitacin I | Medulloblastoma | Radioresistance | STAT3 | Issue Date: | Mar-2012 | Journal Volume: | 28 | Journal Issue: | 3 | Source: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | Abstract: | CD133 (PROM1) is a potential marker for cancer stem cells (CSCs), including those found in brain tumors. Recently, medulloblastoma (MB)-derived CD133-positive cells were found to have CSC-like properties and were proposed to be important contributors to tumorigenicity, cancer progression, and chemoradioresistance. However, the biomolecular pathways and therapeutic targets specific to MB-derived CSCs remain unresolved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639010 | ISSN: | 02567040 | DOI: | 10.1007/s00381-011-1672-x |
Appears in Collections: | 醫學系 |
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