https://scholars.lib.ntu.edu.tw/handle/123456789/639052
Title: | Prospective Application of Tannic Acid in Acetaminophen (APAP)-Induced Acute Liver Failure | Authors: | Lin, Yong Heng Lin, Yu Che YUNG-TE HOU |
Keywords: | acetaminophen-induced liver injury | hepatoprotective and hepatocurative | liver regeneration | tannic acid | Issue Date: | 1-Jan-2024 | Journal Volume: | 25 | Journal Issue: | 1 | Source: | International Journal of Molecular Sciences | Abstract: | This study investigated the effect of tannic acid (TA), a natural plant-derived polyphenol, on hepatocyte viability and function, focusing on both hepatoprotective and hepatocurative aspects within liver failure models. In an in vitro prevention model, the TA-containing group exhibited 1.5-fold and 59-fold higher relative cell viability and albumin synthesis, respectively, in injured mature hepatocytes (MHs) and 1.14-fold and 1.10-fold higher values in injured small hepatocytes (SHs), compared with the TA-free group. In the in vitro curative model, the TA-containing group exhibited 3.25-fold and 113-fold higher relative cell viability and albumin synthesis, respectively, in injured MHs and 0.36-fold and 3.55-fold higher values in injured SHs, compared with the TA-free group. In the in vivo disease model, the administration of 300 μL of 1 μg/mL TA significantly mitigated acute liver failure damage and post-APAP toxicity in mice. This was evident in serum analysis, where the levels of alanine transaminase, aspartate aminotransferase, and total bilirubin notably decreased, in agreement with histological observations. The study findings reveal that TA can enhance hepatic function at specific additive concentrations. Furthermore, even when injured by APAP, hepatocytes could revert to their preinjury state after additional TA supplementation. Additionally, pretreating hepatocytes with TA can alleviate subsequent damage. Thus, TA holds clinical potential in the treatment of APAP-induced liver failure. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181963489&doi=10.3390%2fijms25010317&partnerID=40&md5=f029c692d9d7f70c8c0ee0645823a392 https://scholars.lib.ntu.edu.tw/handle/123456789/639052 |
ISSN: | 16616596 | DOI: | 10.3390/ijms25010317 |
Appears in Collections: | 生物機電工程學系 |
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