標題: | Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study |
作者: | Rizig, Mie Bandres-Ciga, Sara Makarious, Mary B Ojo, Oluwadamilola Omolara Crea, Peter Wild Abiodun, Oladunni Victoria Levine, Kristin S Abubakar, Sani Atta Achoru, Charles Obiora Vitale, Dan Adeniji, Olaleye Akinmola Agabi, Osigwe Paul Koretsky, Mathew J Agulanna, Uchechi Hall, Deborah A Akinyemi, Rufus Olusola Xie, Tao Ali, Mohammed Wulgo Shamim, Ejaz A Ani-Osheku, Ifeyinwa Padmanaban, Mahesh Arigbodi, Ohwotemu Michael Standaert, David G Bello, Abiodun Hamzat Dean, Marissa N Erameh, Cyril Oshomah Elsayed, Inas Farombi, Temitope Hannah Okunoye, Olaitan Fawale, Michael Bimbola Billingsley, Kimberley J Imarhiagbe, Frank Aiwansoba Jerez, Pilar Alvarez Iwuozo, Emmanuel Uzodinma Baker, Breeana Komolafe, Morenikeji Adeyoyin Malik, Laksh Nwani, Paul Osemeke Daida, Kensuke Nwazor, Ernest Okwundu Miano-Burkhardt, Abigail Nyandaiti, Yakub Wilberforce Fang, Zih-Hua Obiabo, Yahaya Olugbo Kluss, Jillian H Odeniyi, Olanike Adedoyin Hernandez, Dena G Odiase, Francis Ehidiamen Tayebi, Nahid Ojini, Francis Ibe Sidranksy, Ellen Onwuegbuzie, Gerald Awele D'Souza, Andrea M Osaigbovo, Godwin Osawaru Berhe, Bahafta Osemwegie, Nosakhare Reed, Xylena Oshinaike, Olajumoke Olufemi Leonard, Hampton L Otubogun, Folajimi Morenikeji Alvarado, Chelsea X Oyakhire, Shyngle Imiewan Ozomma, Simon Izuchukwu Samuel, Sarah Chabiri Taiwo, Funmilola Tolulope Wahab, Kolawole Wasiu Zubair, Yusuf Agboola Iwaki, Hirotaka Kim, Jonggeol Jeffrey Morris, Huw R Hardy, John Nalls, Mike A Heilbron, Karl Norcliffe-Kaufmann, Lucy Blauwendraat, Cornelis Houlden, Henry Singleton, Andrew Okubadejo, Njideka Ulunma CHIN-HSIEN LIN |
公開日期: | 十一月-2023 |
卷: | 22 |
期: | 11 |
起(迄)頁: | 1015 |
來源出版物: | The Lancet. Neurology |
摘要: | An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639113 |
ISSN: | 14744422 |
DOI: | 10.1016/S1474-4422(23)00283-1 |
顯示於: | 醫學院附設醫院 (臺大醫院)
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