Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study
Journal
The Lancet. Neurology
Journal Volume
22
Journal Issue
11
Pages
1015
Date Issued
2023-11
Author(s)
Rizig, Mie
Bandres-Ciga, Sara
Makarious, Mary B
Ojo, Oluwadamilola Omolara
Crea, Peter Wild
Abiodun, Oladunni Victoria
Levine, Kristin S
Abubakar, Sani Atta
Achoru, Charles Obiora
Vitale, Dan
Adeniji, Olaleye Akinmola
Agabi, Osigwe Paul
Koretsky, Mathew J
Agulanna, Uchechi
Hall, Deborah A
Akinyemi, Rufus Olusola
Xie, Tao
Ali, Mohammed Wulgo
Shamim, Ejaz A
Ani-Osheku, Ifeyinwa
Padmanaban, Mahesh
Arigbodi, Ohwotemu Michael
Standaert, David G
Bello, Abiodun Hamzat
Dean, Marissa N
Erameh, Cyril Oshomah
Elsayed, Inas
Farombi, Temitope Hannah
Okunoye, Olaitan
Fawale, Michael Bimbola
Billingsley, Kimberley J
Imarhiagbe, Frank Aiwansoba
Jerez, Pilar Alvarez
Iwuozo, Emmanuel Uzodinma
Baker, Breeana
Komolafe, Morenikeji Adeyoyin
Malik, Laksh
Nwani, Paul Osemeke
Daida, Kensuke
Nwazor, Ernest Okwundu
Miano-Burkhardt, Abigail
Nyandaiti, Yakub Wilberforce
Fang, Zih-Hua
Obiabo, Yahaya Olugbo
Kluss, Jillian H
Odeniyi, Olanike Adedoyin
Hernandez, Dena G
Odiase, Francis Ehidiamen
Tayebi, Nahid
Ojini, Francis Ibe
Sidranksy, Ellen
Onwuegbuzie, Gerald Awele
D'Souza, Andrea M
Osaigbovo, Godwin Osawaru
Berhe, Bahafta
Osemwegie, Nosakhare
Reed, Xylena
Oshinaike, Olajumoke Olufemi
Leonard, Hampton L
Otubogun, Folajimi Morenikeji
Alvarado, Chelsea X
Oyakhire, Shyngle Imiewan
Ozomma, Simon Izuchukwu
Samuel, Sarah Chabiri
Taiwo, Funmilola Tolulope
Wahab, Kolawole Wasiu
Zubair, Yusuf Agboola
Iwaki, Hirotaka
Kim, Jonggeol Jeffrey
Morris, Huw R
Hardy, John
Nalls, Mike A
Heilbron, Karl
Norcliffe-Kaufmann, Lucy
Blauwendraat, Cornelis
Houlden, Henry
Singleton, Andrew
Okubadejo, Njideka Ulunma
Abstract
An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations.
Type
journal article