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Leu W.-J.
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scopus
WOS
全文
2020
Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+/K+-ATPase internalization and tubulin acetylation
Leu W.-J.; Wang C.-T.; Hsu J.-L.; Chen I.-S.; Chang H.-S.; JIH-HWA GUH
Prostate
9
8
2020
The (+)-brevipolide H displays anticancer activity against human castration-resistant prostate cancer: The role of oxidative stress and Akt/mTOR/p70S6K dependent pathways in G1 checkpoint arrest and apoptosis
Sheng Y.-H.; Leu W.-J.; Chen C.-N.; Hsu J.-L.; Liu Y.-T.; LIH-CHING HSU
; Hou D.-R.; JIH-HWA GUH
Molecules
4
4
2015
Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors
Chang Y.-H.; Leu W.-J.; Datta A.; Hsiao H.-C.; Lin C.-H.; JIH-HWA GUH
; Huang J.-H.
Dalton Transactions
17
16
2020
Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies
Leu W.-J.; Chu J.-C.; Hsu J.-L.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU
; Huang W.-J.; JIH-HWA GUH
Molecules (Basel, Switzerland)
8
8
2020
Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancers
Chang Y.-C.; Tseng Y.-L.; Leu W.-J.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU
; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH
International Journal of Molecular Sciences
2
1
2017
Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways
Chan M.-L.; Yu C.-C.; Hsu J.-L.; Leu W.-J.; Chan S.-H.; LIH-CHING HSU
; SHIH-PING LIU
; Ivantcova P.M.; Dogan ?.; Br?se S.; Kudryavtsev K.V.; JIH-HWA GUH
Oncotarget
8
8
2015
Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma
Hsu J.-L.; Liu F.-L.; LIH-CHING HSU
; Chang H.-S.; Leu W.-J.; Yu C.-C.; Chang W.-L.; Chen I.-S.; FAN-LU KUNG
; JIH-HWA GUH
Oncotarget
6
5
2020
Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells
Huang T.-E.; Deng Y.-N.; Hsu J.-L.; Leu W.-J.; Marchesi E.; Capobianco M.L.; Marchetti P.; Navacchia M.L.; JIH-HWA GUH
; Perrone D.; LIH-CHING HSU
Frontiers in Pharmacology
19
18
2019
Extract from plectranthus amboinicus inhibit maturation and release of interleukin 1β through inhibition of NF-κB nuclear translocation and NLRP3 inflammasome activation
Leu W.-J.; Chen J.-C.; JIH-HWA GUH
Frontiers in Pharmacology
28
29
2020
Mechanistic study of triazole based aminodiol derivatives in leukemic cells—crosstalk between mitochondrial stress-involved apoptosis and autophagy
Chan S.-H.; Leu W.-J.; Swain S.P.; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH
International Journal of Molecular Sciences
1
2
2014
Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer
Hsu J.-L.; Lee Y.-J.; Leu W.-J.; Dong Y.-S.; Pan S.-L.; Uang B.-J.; JIH-HWA GUH
Journal of Urology
12
11
2016
Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: The role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways
Leu W.-J.; Swain S.P.; Chan S.-H.; Hsu J.-L.; SHIH-PING LIU
; Chan M.-L.; Yu C.-C.; LIH-CHING HSU
; Chou Y.-L.; Chang W.-L.; Hou D.-R.; JIH-HWA GUH
Oncotarget
14
14
2018
Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR/p70S6K pathway: Roles of lipid raft and cholesterol contents
Hsu J.-L.; Leu W.-J.; LIH-CHING HSU
; SHIH-PING LIU
; Zhong N.-S.; JIH-HWA GUH
Frontiers in Pharmacology
10
19
2019
Phosphodiesterase type 5 (PDE5) inhibitors sensitize topoisomerase II inhibitors in killing prostate cancer through PDE5-independent impairment of HR and NHEJ DNA repair systems
Chang J.-F.; Hsu J.-L.; Sheng Y.-H.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Chan M.-L.; LIH-CHING HSU
; SHIH-PING LIU
; JIH-HWA GUH
Frontiers in Oncology
11
13
2020
Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling
Hsu J.-L.; Leu W.-J.; LIH-CHING HSU
; Ho C.-H.; SHIH-PING LIU
; JIH-HWA GUH
Frontiers in Oncology
11
9
2014
Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle
Leu W.-J.; Chang H.-S.; Chan S.-H.; Hsu J.-L.; Yu C.-C.; LIH-CHING HSU
; Chen I.-S.; JIH-HWA GUH
PLoS ONE
26
24
2013
Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades
Chan S.-H.; Leu W.-J.; LIH-CHING HSU
; Chang H.-S.; Hwang T.-L.; Chen I.-S.; Chen C.-S.; JIH-HWA GUH
Biochemical Pharmacology
17
15
2015
Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - A crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation
Chang W.-L.; LIH-CHING HSU
; Leu W.-J.; Chen C.-S.; JIH-HWA GUH
Oncotarget
39
35
2018
Ruthenium (II) complexes containing dehydroacetic acid and its imine derivative ligands. Synthesis, characterization and cancer cell growth anti-proliferation activity (GI50) study
Chen K.-H.; Lin T.-H.; Hsu T.-E.; Li Y.-J.; Chen G.-H.; Leu W.-J.; JIH-HWA GUH
; Lin C.-H.; Huang J.-H.
Journal of Organometallic Chemistry
8
6
2016
Synthesis and characterization of ruthenium compounds incorporating keto-amine ligands. The applications of catalytic transfer hydrogenation and cancer cell inhibition
Lin T.-H.; Das K.; Datta A.; Leu W.-J.; Hsiao H.-C.; Lin C.-H.; JIH-HWA GUH
; Huang J.-H.
Journal of Organometallic Chemistry
8
8