https://scholars.lib.ntu.edu.tw/handle/123456789/564761
標題: | Ruthenium (II) complexes containing dehydroacetic acid and its imine derivative ligands. Synthesis, characterization and cancer cell growth anti-proliferation activity (GI50) study | 作者: | Chen K.-H. Lin T.-H. Hsu T.-E. Li Y.-J. Chen G.-H. Leu W.-J. JIH-HWA GUH Lin C.-H. Huang J.-H. |
關鍵字: | Anti-proliferation activity; Cancer cell; Dehydroacetic acid; Imine; Ruthenium | 公開日期: | 2018 | 卷: | 871 | 起(迄)頁: | 150-158 | 來源出版物: | Journal of Organometallic Chemistry | 摘要: | Two dehydroacetic acid (DHA, L1H) related imine ligands, L2H and L3H were obtained in moderate yields by reacting DHA with 2,4,6-trimethylaniline and phenylhydrazine, respectively. Refluxing [Ru (η6-p-cymene)Cl2]2 with two equivalents of L1Na, L2H and L3H in methanol generated ruthenium compounds [Ru (η6-p-cymene)Cl (L1)] (1), [Ru (η6-p-cymene)Cl (L2)] (2), [Ru (η6-p-cymene)Cl (L3)] (3), respectively. The chloride atom of 2 and 3 was substituted by ambidentate ligands N3, NCO and NCS to generate a series of ruthenium compounds 4a-4c and 5a-5b. All of these ligands and ruthenium compounds were characterized by 1H and 13C NMR spectroscopy. Compounds 1–3, 4a-4c, and 5a were also structural determined by single crystal X-ray crystallography showing a three-legged piano stool geometry with the p-cymene acting as the seat plane. Anti-proliferative activity study using these ruthenium complexes against PC-3 and DU-145 cell-lines shows that compounds 2 and 4a-4c have the best activity than other ruthenium compounds. The results indicate that the ruthenium p-cymene compounds with large steric hindrance of dehydroacetic acid imine derivative ligands exhibit higher anti-proliferative activity against PC-3 and DU-145 cell-lines. ? 2018 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049961183&doi=10.1016%2fj.jorganchem.2018.07.014&partnerID=40&md5=0dd6956497ceb1a510e2a7ba86da0187 https://scholars.lib.ntu.edu.tw/handle/123456789/564761 |
ISSN: | 0022328X | DOI: | 10.1016/j.jorganchem.2018.07.014 | SDG/關鍵字: | Cell culture; Cell proliferation; Cells; Chlorine compounds; Diseases; Ligands; Nuclear magnetic resonance spectroscopy; Organic polymers; Ruthenium; Single crystals; X ray crystallography; 13C NMR spectroscopy; Anti-proliferation activities; Anti-proliferative activities; Cancer cells; Dehydroacetic acids; Imine; Piano stool geometry; Single crystal X-ray crystallography; Ruthenium compounds |
顯示於: | 藥學系 |
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