TIEN-JYUN CHANG
張恬君
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| Organization | Role |
Associate Professor | |
Attending Physician |
Email
tjc922@gmail.com
ORCID
Scopus Author ID
Research Interests
Diabetes an other metabolic disease
Physiology, pathology, pharmacology, and molecular biology of islets
Genetic epidemiology of diabetes and obesity
Endocrine disease
Organization
| Organization | Major | Role | Start | End |
National Taiwan University | Graduate Institute of Clinical Medicine, College of Medicine | Ph.D. | ||
Kaohsiung Medical University | School of Medicine, College of Medicine | M.D. |
Organization
| Organization | Dept | Title | Start |
National Taiwan University | Department of Internal Medicine, College of Medicine | Associate Professor | August 2024 |
National Taiwan University Hospital | Division of Metabolism and Endocrinology, Department of Internal Medicine | Attending Physician |
Organization
| Organization | Dept | Title | Start | End |
National Taiwan University | Department of Internal Medicine, College of Medicine | Clinical Associate Professor | August 2016 | July 2024 |
National Taiwan University | Department of Internal Medicine, College of Medicine | Clinical Assistant Professor | ||
National Taiwan University | Department of Internal Medicine, College of Medicine | Instructor | ||
En-Chu-Kong Hospital | Department of Internal Medicine | Attending Physician | ||
En-Chu-Kong Hospital | Department of Internal Medicine | Chief Resident | ||
National Taiwan University Hospital | Department of Internal Medicine | Resident | ||
Kaohsiung Medical University Chung-Ho Memorial Hospital | Department of Internal Medicine | Resident |
Achievement(s)
We found that rosiglitazone (one of anti-diabetic drug) activates AMPK activity, and then enhances the phosphorylation of S385 of Kir6.2, and inhibits current of KATP channel, then elevates the membrane potential of β cells, ultimately leads to stimulate insulin secretion (Diabetologia 2009; 52 (6):1112-1121). We also found that Islet neogenesis associated protein (INGAP) stimulates experimental p