This study was based on diffusion of innovation theory (DOI) to analyze the secondary database of Keelung Community-based Integrated Screening Cohort (KCIS). The current study aims to realize and retrospect the adoptive pattern of KCIS cohort from year 2000 to 2009. KCIS program screened for 3 chronic diseases and 5 cancers as the innovative services, inviting all family members in communities. KCIS datasets collected the anthropometric measures, biochemical assays and lifestyle questionnaires during screening process under the approval of the city government. This study will use diabetes mellitus as a DOI model to explore the association and related factors for familial aggregation and trans-generative diffusion experience. The integrated screening, referral, management and analysis will be studied to reveal the condition of “real world” in the 10 year period. The impact of significant factors for diffusion will be found. The familial aggregation and trans-generation will be explained for diabetes mellitus. All the results can be important references for community screening in the future.