Application of point-of-care ultrasound (PoCUS) is getting more and more popular due to advance of technology and the non-invasiveness of the procedure. Motivation and learning needs of PoCUS training from medical students are increasing significantly. However, traditional specialty-specific ultrasound training has not been suitable to adopt for PoCUS training. Besides, traditional training modalities cannot assure the comprehensiveness and quality of training. Much more faculty for PoCUS training are required to meet the rapidly increasing learning needs. This topic of this project is “Paradigm Shift of Point-of-Care Ultrasound (PoCUS) Education”. Formal PoCUS curriculum will be conducted into clinical training of medical students. An experimental study design was performed to explore: 1. the effect and reaction of trainees to application of i-AIM framework (Indications, Acquisition, Interpretation, and Management integration) in PoCUS training. 2. the effects of implementing near-peer teaching (NPT) in PoCUS training. More sample collection was necessary to explore the significance of the training effectiveness. The effects of this project involve multiple dimensions of PoCUS education including comprehensive training models, educational framework, training modalities, and faculty development. These will offer evidence-based experiences and bring fundamental paradigm shift ofPoCUS education. Structured PoCUS training model is proved to be effective in training and assessment. Comprehensive faculty development and more sample collection are required to validate the effects of NPT.