Project title
東亞特有乙醛去氫酶變異之基因敲入鼠模式引發腎功能不全:其促進劑之療效 (I)
Internal ID
NSTC113-2314-B002-297
Principal Investigator
Start Date
August 1, 2024
End Date
July 31, 2025
Investigators
Organizations
Partner Organizations
The Mechanism by Which East Asian-Specific Aldh2 Mutation Causes Renal Insufficiency: Therapeutic Efficacy of Aldh2 Agonist (I)
Keywords
ALDH2
diabetic nephropathy
acute kidney injury
AD9308
4-HNE
Description
本研究目的是發展降低有毒醛類之小分子藥物 以治療慢性腎病變與急性腎衰竭, 並探討其分子機轉。基於此小分子藥物以證明的臨床安全性, 及其在多種腎病變明確的療效，在目前腎臟衰竭藥物尚未有未臻完善的處境下，本研究極可能轉譯為國人腎病有效臨床治療。