Identify Han Chinese Population-Specific Genetic Mutations in Patients with Tetralogy of Fallot and Develop a Genetic Risk Prediction Model for Clinical Practice (I)

Project title

精進法洛氏四重症術後長期治療成果:以減少血行、電生理、代謝及併行基因異常多重風險為導向之策略-尋找法洛氏四重症患者漢族人群特異性基因突變並開發用於臨床病人照顧的遺傳風險預測模型(1/3)

Internal ID

NSTC112-2314-B002-293

Principal Investigator

Start Date

August 1, 2023

End Date

July 31, 2024

Investigators

Organizations

Partner Organizations

Keywords

Tetralogy of Fallot

population-specific TOF mutations

genetic risk scores

Description

華人法洛氏四重症臨床資料及特有的基因突變資料仍少，建構心律不整,右心衰竭的早期風險評估工具,是臨床重要的參考。建構危險預測模式，將可預測病人未來心律不整發作，心衰竭的風險，提早藥物劑量或種類調整，降低再發作機會，另外可協助國家制定法洛氏四重症病童的最佳治療策略.