An Integrated Structural, Biochemical, and Computational Dissection of the Assembly and Operation of the Type II Topoisomerase-Mediated DNA Gate

Project title

探討第二型拓撲酶主導之DNA閘門的形成及其運作機制：基於結構生物學、生物化學、與理論計算的整合性分析

Internal ID

MOST106-2113-M002-021-MY3

Principal Investigator

Start Date

August 1, 2017

End Date

July 31, 2018

Partner Organizations

Keywords

第二型DNA 拓撲異構酶

DNA 分子閘門

蛋白質與DNA 之交互作用

蛋白質-DNA 複合體之構形變化

生物巨分子X-射線晶體結構解析

type II DNA topoisomerase

enzyme-mediated DNA-gate

protein-DNA interactions

conformational change of protein-DNA complex

macromolecular X-ray crystallography