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.National Taiwan University / 國立臺灣大學
Project / 研究計畫
Identification and Characterization of Prognostic Biomarkers in Host Metabolomic Profiling for Patients with Candidemia (I)
Identification and Characterization of Prognostic Biomarkers in Host Metabolomic Profiling for Patients with Candidemia (I)
Details
Primary Data
Project title
探討如何改善管控熱帶念珠菌感染-念珠菌菌血症病人血清代謝體預後生物標記的識別及特徵分析 (I)
Internal ID
NSTC113-2314-B002-299
Principal Investigator
YEE-CHUN CHEN
Start Date
August 1, 2024
End Date
July 31, 2025
Investigators
PAO-YU CHEN
嚴玉婷
HSIN-YUN SUN
Organizations
Internal Medicine
Partner Organizations
National Science and Technology Council
Description
Keywords
candidemia
bloodstream infection
invasive candidiasis
metabolomics
mass spectrometry
prognosis
biomarker
prediction
death
persistent candidemia
hepatosplenic candidiasis
precision medicine
Description
這個由五個部分組成的三年整合型計畫的最終目標是透過從「健康一體」的角度尋求更好的管理策略,以減少念珠菌,特別是抗藥性熱帶念珠菌對人類健康的威脅。 我們希望透過比較來自病人和環境的熱帶念珠菌株,並確定導致熱帶念珠菌抗藥性的分子機制;研究白色念珠菌和熱帶念珠菌菌血症成人病人血清中潛在的預後代謝生物標記物,了解與疾病嚴重程度相關的遺傳變異和轉錄譜,闡明動物模型上的宿主-病原體相互作用,並尋求潛在的治療解決方案。
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