Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer
Journal
The Prostate
Journal Volume
83
Journal Issue
16
Pages
1549
Date Issued
2023-12
Author(s)
Chiang, Yi-Chang
Leu, Wohn-Jenn
Chen, Yi-Chin
Ye, Pei-Chen
Hsu, Yu-Tung
Hsiao, Yu-Chi
Hsu, Jui-Ling
Chan, She-Hung
Huang, Hsu-Shan
Abstract
Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment and the therapeutic options are continuously advancing. This study aims to discover the anti-CRPC effects and underlying mechanisms of small-molecule compounds targeting topoisomerase (TOP) II and cellular components of DNA damage repair.
Subjects
G2 arrest; Rad51 inhibition; castration-resistant prostate cancer; dual function inhibitors; topoisomerase II inhibitors
SDGs
Type
journal article