https://scholars.lib.ntu.edu.tw/handle/123456789/641120
標題: | Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer | 作者: | Chiang, Yi-Chang Leu, Wohn-Jenn Chen, Yi-Chin Ye, Pei-Chen Hsu, Yu-Tung Hsiao, Yu-Chi Hsu, Jui-Ling Chan, She-Hung LIH-CHING HSU Huang, Hsu-Shan JIH-HWA GUH |
關鍵字: | G2 arrest; Rad51 inhibition; castration-resistant prostate cancer; dual function inhibitors; topoisomerase II inhibitors | 公開日期: | 十二月-2023 | 卷: | 83 | 期: | 16 | 起(迄)頁: | 1549 | 來源出版物: | The Prostate | 摘要: | Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment and the therapeutic options are continuously advancing. This study aims to discover the anti-CRPC effects and underlying mechanisms of small-molecule compounds targeting topoisomerase (TOP) II and cellular components of DNA damage repair. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641120 | ISSN: | 02704137 | DOI: | 10.1002/pros.24613 |
顯示於: | 藥學系 |
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