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Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity
Journal
The Journal of allergy and clinical immunology
Journal Volume
149
Journal Issue
1
Pages
24
End Page
28
Date Issued
2022
Author(s)
Holland, Steven M
Abstract
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.
Subjects
Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis
Publisher
MOSBY-ELSEVIER
Type
journal article