|Title:||Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity||Authors:||ARISTINE CHENG
Holland, Steven M
|Keywords:||Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis||Issue Date:||2022||Publisher:||MOSBY-ELSEVIER||Journal Volume:||149||Journal Issue:||1||Start page/Pages:||24||Source:||The Journal of allergy and clinical immunology||Abstract:||
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.
|Appears in Collections:||醫學系|
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