SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes
Journal
BMC medical genetics
Journal Volume
11
Journal Issue
1
Date Issued
2010-08-25
Author(s)
Chiu, Yen-Feng
Lin, Wen-Hsing
Yuan, Hsiang-Yu
Chen, Yuan-Tsong
Abstract
Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes.
Subjects
TORTUOSITY-SYNDROME; VASCULAR-DISEASE; RISK-FACTORS; LOWER-EXTREMITY; COMPLICATIONS; POPULATION; ASSOCIATION; MUTATIONS; TRAITS
SDGs
Publisher
BMC
Type
journal article