Urothelial Carcinomas of the Urinary Bladder With Plasmacytoid or Rhabdoid Features and Tendency of Epithelial-Mesenchymal Transition in 3 Dogs.
Journal
Veterinary pathology
Journal Volume
55
Journal Issue
5
Pages
673-677
Date Issued
2018
Author(s)
Lin, Susanne Je-Han
Kao, Chi-Fei
Wang, Fun-In
Jeng, Chian-Ren
Lee, Jih-Jong
Wang, Lei-Ya
Chang, Hui-Wen
Chen, Yi-Jiun
Liu, Chen-Hsuan
Abstract
Plasmacytoid and rhabdoid variants of urothelial carcinomas (UCs) of the urinary bladder have been described in humans with plasma cell–like or rhabdoid cellular appearance and aggressive clinical outcome. Canine UC of the bladder is generally classified as papillary/nonpapillary and infiltrating/noninfiltrating with limited information regarding other histological patterns. We report 3 cases of UC of the urinary bladder showing a unique discohesive cellular morphology with malignant behavior resembling the human plasmacytoid and rhabdoid variants of UC, which may raise some difficulties in diagnosis. Epithelial-mesenchymal transition and reduced E-cadherin expression were revealed by immunohistochemistry in 2 cases, possibly explaining the discohesive and invasive behavior of the tumor cells. The findings broaden the morphological spectrum as well as the distinct clinical features of canine UC of the urinary bladder. ? The Author(s) 2018.
SDGs
Other Subjects
carboplatin; melan A; mitoxantrone; uroplakin 3; uvomorulin; vimentin; cadherin; animal tissue; Article; autopsy; bladder biopsy; bladder carcinoma; cancer chemotherapy; clinical feature; cystotomy; disease duration; disseminated intravascular clotting; dysuria; epithelial mesenchymal transition; female; hematuria; hydronephrosis; immunohistochemistry; male; metastasis; nonhuman; protein expression; renography; schnauzer; Shetland sheepdog; transitional cell carcinoma; urinary bladder urothelial carcinoma; urinary bladder urothelial carcinoma; urine incontinence; animal; bladder; bladder tumor; carcinoma; case report; cytology; dog; dog disease; epithelial mesenchymal transition; metabolism; pathology; urothelium; veterinary medicine; Animals; Cadherins; Carcinoma; Dog Diseases; Dogs; Epithelial-Mesenchymal Transition; Female; Male; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium
Type
journal article