https://scholars.lib.ntu.edu.tw/handle/123456789/416497
標題: | Urothelial Carcinomas of the Urinary Bladder With Plasmacytoid or Rhabdoid Features and Tendency of Epithelial-Mesenchymal Transition in 3 Dogs. | 作者: | CHIAN-REN JENG Lin, Susanne Je-Han Kao, Chi-Fei Wang, Fun-In Jeng, Chian-Ren Lee, Jih-Jong Wang, Lei-Ya Chang, Hui-Wen Chen, Yi-Jiun Liu, Chen-Hsuan JIH-JONG LEE HUI-WEN CHANG VICTOR FEI PANG |
公開日期: | 2018 | 卷: | 55 | 期: | 5 | 起(迄)頁: | 673-677 | 來源出版物: | Veterinary pathology | 摘要: | Plasmacytoid and rhabdoid variants of urothelial carcinomas (UCs) of the urinary bladder have been described in humans with plasma cell–like or rhabdoid cellular appearance and aggressive clinical outcome. Canine UC of the bladder is generally classified as papillary/nonpapillary and infiltrating/noninfiltrating with limited information regarding other histological patterns. We report 3 cases of UC of the urinary bladder showing a unique discohesive cellular morphology with malignant behavior resembling the human plasmacytoid and rhabdoid variants of UC, which may raise some difficulties in diagnosis. Epithelial-mesenchymal transition and reduced E-cadherin expression were revealed by immunohistochemistry in 2 cases, possibly explaining the discohesive and invasive behavior of the tumor cells. The findings broaden the morphological spectrum as well as the distinct clinical features of canine UC of the urinary bladder. ? The Author(s) 2018. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/416497 | ISSN: | 1544-2217 0300-9858 | DOI: | 10.1177/0300985818771151 | SDG/關鍵字: | carboplatin; melan A; mitoxantrone; uroplakin 3; uvomorulin; vimentin; cadherin; animal tissue; Article; autopsy; bladder biopsy; bladder carcinoma; cancer chemotherapy; clinical feature; cystotomy; disease duration; disseminated intravascular clotting; dysuria; epithelial mesenchymal transition; female; hematuria; hydronephrosis; immunohistochemistry; male; metastasis; nonhuman; protein expression; renography; schnauzer; Shetland sheepdog; transitional cell carcinoma; urinary bladder urothelial carcinoma; urinary bladder urothelial carcinoma; urine incontinence; animal; bladder; bladder tumor; carcinoma; case report; cytology; dog; dog disease; epithelial mesenchymal transition; metabolism; pathology; urothelium; veterinary medicine; Animals; Cadherins; Carcinoma; Dog Diseases; Dogs; Epithelial-Mesenchymal Transition; Female; Male; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium |
顯示於: | 獸醫學系 |
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