Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve
Journal
Frontiers in neuroscience
Journal Volume
17
Date Issued
2023
Author(s)
Chen, Szu-Han
Wu, Chia-Ching
Tseng, Wan-Ling
Lu, Fu-I
Liu, Ya-Hsin
Lin, Sheng-Che
Hsueh, Yuan-Yu
Abstract
Compressive neuropathy, a common chronic traumatic injury of peripheral nerves, leads to variable impairment in sensory and motor function. Clinical symptoms persist in a significant portion of patients despite decompression, with muscle atrophy and persistent neuropathic pain affecting 10%-25% of cases. Excessive inflammation and immune cell infiltration in the injured nerve hinder axon regeneration and functional recovery. Although adipose-derived stem cells (ASCs) have demonstrated neural regeneration and immunomodulatory potential, their specific effects on compressive neuropathy are still unclear.
Subjects
adipose derived stem cells; chronic constriction injury; compressive neuropathy; immunomodulation; neuroinflammation; neuropathic pain; stem cell therapy
SDGs
Type
journal article